At least 10 people are feared dead and many more injured after two high-speed trains collided in Toledo province in central Spain on Wednesday morning.

Spain's state rail infrastructure authority confirmed that services between Madrid and the southern region of Andalucia had been suspended following what it described as "a rear-end collision between two trains."

The crash occurred in Urda, in the Castilla-La Mancha region. A spokesperson for the regional government said the cause and the number of injuries had yet to be determined.

Government sources told Spanish newspaper El Pais that at least 10 people had been killed, and warned the final toll could surpass that of the Adamuz rail disaster in January, in which 46 people died.

A local government spokesperson told Spanish public broadcaster TVE that the death toll "will almost certainly rise." Esther Padilla told the broadcaster that "the situation is going to worsen."

According to reports, the trains involved are believed to be Iryo 7076, carrying 146 passengers and one infant, and AVE 2080, carrying 397 passengers.