A Russian airstrike has destroyed a school used as a humanitarian aid centre in the village of Komyshuvakha in Ukraine's southeastern Zaporizhia region, killing at least 24 people, according to Ukrainian President Volodymyr Zelenskyy.

Five people were reported injured in the strike. Regional Governor Mykhailo Semikin confirmed that 27 people remained missing and that rescue teams were working at the scene.

Zelenskyy initially reported a death toll of 18. Ukraine's State Emergency Service later confirmed 24 people had been killed, including two rescuers and four police officers.

"After the first air strike, there was a repeat strike with nine more bombs, directly on the shelter where people were gathered," Zelenskyy wrote on Telegram.

Footage released by Ukrainian emergency services showed the building reduced to piles of smouldering rubble, with rescuers working at the site.

Semikin described the attack as a "terrible tragedy" for the village and confirmed that "people are still under the rubble." He said rescue teams were forced to halt their operation several times due to Russian drone activity in the area.

Zelenskyy said the attack was deliberate, arguing Russian forces were fully aware the site was used for weekly humanitarian distributions to local residents who had remained in the village.

"The Russians could not have been unaware that the local residents who remained in Komyshuvakha received humanitarian aid there every week," he wrote. "This is yet another proof that Russia does not want any de-escalation."

The Ukrainian president linked the strike to a recent joint Russian-Ukrainian civilian evacuation operation in the Russia-occupied southern city of Oleshky, saying the operation had briefly suggested progress toward peace was possible.

"After the humanitarian operation in Oleshky, there was a moment when the next steps could have shown that progress toward peace was possible," Zelenskyy said. "With these killings, Russia is sending an entirely opposite signal: Russia is counting on more killings."

The Russian military has not publicly commented on the strike.

Elsewhere in Ukraine, emergency services reported that drone strikes injured 12 people in the eastern Kharkiv region and damaged a refrigeration facility, greenhouses and residential buildings.

Five people were also reported injured in the Black Sea port city of Odesa, where a warehouse was targeted and homes were damaged.

Russia's Ministry of Defence said it had shot down 212 Ukrainian drones overnight. The head of Russia's Samara region reported that local air defences had repelled an aerial attack, without providing further details.

Russia launched a full-scale invasion of Ukraine in February 2022.