An Amazon Prime Air cargo plane overran a runway at Miami International Airport on Sunday, triggering a major emergency response and leaving multiple people injured.

The Federal Aviation Administration confirmed that Prime Air Flight 7598 overshot the runway while landing at approximately 2 p.m. ET. The flight had departed from Luis Munoz Marin International Airport in San Juan, Puerto Rico.

Video posted on social media showed the Boeing 767 off the runway with its tail over the perimeter fence and thick black smoke rising from the aircraft.

Miami-Dade Fire Rescue confirmed there were "multiple patients" and said firefighters were working to extinguish the fire. The agency described it as an active scene, with more than 60 units responding. It was not immediately clear whether anyone had been killed.

The Miami-Dade Aviation Department said the plane overran the diagonal runway and came to rest disabled at the northwest end of the airport. "All runways and taxiways at MIA are currently closed as of 3:00 p.m.," the department said in a statement.

The FAA issued a ground stop on all arriving aircraft, initially until 3 p.m., which was later extended to 5:30 p.m. Transportation Secretary Sean Duffy said the ground stop was ordered to allow first responders to assess the scene and warned travelers of "significant delays and potential cancellations."

The FAA said it would investigate the crash.

At the time of the incident, the aircraft was being operated by contract cargo carrier 21 Air, according to Amazon spokesperson Kelly Nantel.

"This is a fast-moving situation and we're still gathering details. We're working closely with local authorities and officials to understand exactly what happened," Nantel said. "Right now, our absolute priority is the safety, well-being, and care of everyone involved. We're doing everything we can to support those affected."